Year: 2019 | Volume: 1 | Issue: 1 | Page No.: 1-8
Recieved: December 09, 2019 Accepted: December 11, 2019 Published: December 31, 2019
Comparison of Cytochrome P450-Mediated Drug Metabolism in Cats and Dogs
Theophylline (THP), Phenytoin (PHT), Metoprolol (MTP) and Quinidine (QUN) were intravenously administrated to cats and dogs in order to compare the pharmacokinetic parameters between both species. Dose of THP 5 mg/Kg to cats and dogs, PHT 1 mg/Kg to cats and 5 mg/kg to dogs, MTP and QUN 2 mg/Kg to cats and dogs were intravenously injected to the animals with a washout period of 4-6 weeks. A high performance liquid chromatography method was used to determine plasma concentrations. Plasma concentrations plotted against time on semilogarithmic coordinates indicated that pharmacokinetics of all the four drugs best fitted to 1-compartment open model. Total body clearance (Cltot) of PHT in cats was much smaller (1/26) than dogs with quite long elimination half-life (102 ± 17 hr), suggesting that CYP2C activities of cats are extremely low. This suggests that CYP2C substrate should be carefully administrated to cat. The Cltot of QUN in cats was 4-folds higher than dogs. While MTP substrate of CYP2D demonstrated similar activity to that of dogs. THP pharmacokinetics showed moderate activities in cat but compared with dog THP was slightly small in cats. These results suggest that CYP1A substrate should be prescribed similar to dogs and CYP3A in cats using different dosage regimen than dogs.
Comparison, CYP450, Drug metabolism, Cats, Dogs
TO CITE THIS ARTICLE
Syed Sher Shah Sadaat, Farid Ahmad Tanin, Abdul Razaq Irshad, Amanullah Aziz and Kazuki Sasaki
2019. Comparison of Cytochrome P450-Mediated Drug Metabolism in Cats and Dogs. Journal of Clinical Pharmacology and Pharmaceutical Research, 1: 1-8